User:Mr. Ibrahem/Goserelin
Clinical data | |
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Trade names | Zoladex, others |
Other names | D-Ser(But)6Azgly10-GnRH |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601002 |
Pregnancy category |
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Routes of administration | Implant |
Drug class | GnRH analogue; GnRH agonist; Antigonadotropin |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 27.3% |
Elimination half-life | 4–5 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C59H84N18O14 |
Molar mass | 1269.433 g·mol−1 |
3D model (JSmol) | |
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Goserelin, sold under the brand name Zoladex among others, is a medication used to treat prostate cancer, breast cancer, endometriosis, dysfunctional uterine bleeding, and uterine fibroids.[1][2] In prostate cancer it may be used instead of testicle removal.[2] It is given by injection under the skin.[1]
Common side effects include hot flushes, sexual dysfunction, depression, and pain.[2] Other side effects may include pituitary apoplexy, QT prolongation, osteoporosis, and anaphylaxis.[2]> Use in pregnancy may harm the baby.[2] It is a gonadotropin releasing hormone agonist (GnRH agonist) which results in decreased follicle stimulating hormone (FSH) and luteinising hormone (LH) followed by decreased androgen and estrogen.[1]
Goserelin was patented in 1976 and approved for medical use in 1987.[3] It is on the World Health Organization's List of Essential Medicines as an alternative to leuprorelin.[4] In the United Kingdom a 3.6 mg implant costs the NHS about £70 as of 2021.[1] This amount in the United States is about 600 USD.[5]
References[edit]
- ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 780. ISBN 978-0857114105.
- ^ a b c d e f "Goserelin Monograph for Professionals". Drugs.com. Archived from the original on 28 November 2021. Retrieved 9 December 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 514. ISBN 9783527607495. Archived from the original on 2021-06-20. Retrieved 2021-10-04.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "Goserelin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 December 2021.