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User:Mr. Ibrahem/Dexrazoxane

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Mr. Ibrahem/Dexrazoxane
Clinical data
Trade namesZinecard, Cardioxane, others
Other namesDexrazoxane hydrochloride
AHFS/Drugs.comMonograph
MedlinePlusa609010
License data
Routes of
administration		Intravenous
Legal status
Legal status
Identifiers
  • 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
Chemical and physical data
FormulaC11H16N4O4
Molar mass268.273 g·mol−1
3D model (JSmol)
  • O=C2NC(=O)CN(C[C@@H](N1CC(=O)NC(=O)C1)C)C2
  • InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1 checkY
  • Key:BMKDZUISNHGIBY-ZETCQYMHSA-N checkY
  (verify)

Dexrazoxane, sold under the brand name Zinecard among others, is a medication used to prevent cardiomyopathy due to doxorubicin and in extravasation of anthracyclines.[1][2] It is given by injection into a vein.[1]

Common side effects include pain at the site of injection, nausea, and diarrhea.[3][1] Other side effects may include bone marrow suppression.[3] In children in may increase the risk of further cancers.[4] It is an antidote to anthracyclines.[2]

Dexrazoxane was discovered in 1972.[4] It was approved for medical use in the United States in 1995 and Europe in 2006.[1][2] In the United States 500 mg costs about 420 USD as of 2021.[5] This amount in the United Kingdom is about £160.[6]

References[edit]

  1. ^ a b c d e "Dexrazoxane Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 23 December 2021.
  2. ^ a b c d "Savene". Archived from the original on 12 November 2020. Retrieved 23 December 2021.
  3. ^ a b c "DailyMed - DEXRAZOXANE- dexrazoxane for injection injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 26 March 2021. Retrieved 23 December 2021.
  4. ^ a b Kim, Kyu-Won; Roh, Jae Kyung; Wee, Hee-Jun; Kim, Chan (14 November 2016). Cancer Drug Discovery: Science and History. Springer. p. 250. ISBN 978-94-024-0844-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
  5. ^ "Dexrazoxane Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 April 2021. Retrieved 23 December 2021.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 984. ISBN 978-0857114105.
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